Metabolic and genetic aspects of thiopurine metabolism dr. J.A. Bakker Chapter 01 – Introduction Chapter 02 – Selectivity of TPMT towards thiopurine nucleosides and nucleotides Chapter 03 – Quantitative measurement of thiopurine metabolites in biological fluids using ultraperformance liquid chromatographytandem mass spectometry Chapter 04 – Azathioprine induced pneumonitis in a patient with ulcerative colitis Chapter 05 – A comparative study of inosine triphosphatase activity in fresh erythrocytes and dried blood spots Chapter 06 – The effect of ITPA polymorphisms on the enzyme kinetic properties of human erythrocyte inosine triphosphatase towards its substrates ITP and 6-thio-ITP Effects of ITPA polymorphism on ITPase kinetics Chapter 07 – Role for ITPA variants in the clinical course of pulmonary Langerhans’cell histiocytosis? ITPA polymorphisms in PLCH Chapter 08 – General discussion Chapter 09 – Summary Chapter 10 – Samenvatting Chapter 11 – List of publications Chapter 12 – Dankwoord Chapter 13 – Curriculum vitae Back
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